Antimicrobial, anti-biofilm and cytotoxic properties of methallyl functionalized benzimidazolium-derived Ag(I)-Nheterocyclic carbene complexes

Purpose: To investigate the antimicrobial, antibiofilm, and cytotoxicity properties of methallyl substituted benzimidazolium-based, silver-bound N-heterocyclic carbene (Ag(I)-NHC) complexes, with respect to their potential act as antimicrobial agents.Methods: The four synthesis characterization which were carried out previously, investigated. tested using broth microdilution method, while antibiofilm determined by microtiter plate assay. L-929 cell line was used for cytotoxic studies.Results: Strong effects produced Ag(I)-NHC complexes. Compounds 2 3 showed potent activities against E. coli strain, similar that positive control antibiotic, compounds 1 4 exhibited activity at a concentration 31.2 μg/mL. effective biofilms formed concentrations in range 32 – 84 %, degraded mature 14 - 66 %. did not significantly affect survival (p > 0.05), reduced survival, when compared untreated cells group < 0.001).Conclusion: This study may be one few studies on benzimidazolium-derived NHCs. this valuable novel agents. Therefore, there is need further vivo vitro these compounds.